What is the action of quinine on malarial parasite?

Quinine acts on the malarial parasite primarily by inhibiting its ability to metabolize and detoxify heme, a byproduct of hemoglobin digestion. This leads to the accumulation of toxic heme, which ultimately disrupts the parasite's cellular processes and promotes its death. Quinine also interferes with the parasite's ability to reproduce within red blood cells, contributing to its effectiveness as an antimalarial treatment.