To remove Domino Server settings in Lotus Notes 8.5, go to the "File" menu, select "Preferences," and then navigate to "Mail" to adjust or delete existing SMTP configurations. To set up SMTP, access the "Servers" tab in the Domino Administrator client, select "Configuration," and add a new SMTP server if needed. Ensure you configure the necessary settings, including the server name, host name, and any authentication requirements. Finally, restart the Domino server to apply the changes.
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