How can I prevent my meatloaf from falling apart while cooking?

To prevent meatloaf from falling apart while cooking, make sure to use a binding agent like eggs or breadcrumbs to hold the ingredients together. Additionally, avoid overmixing the meat mixture and handle it gently when shaping the loaf. Finally, bake the meatloaf on a rack in a pan to allow excess fat to drain away, helping it hold its shape.