There is no significance since there is no Act 8 Scene 8 in the play "Macbeth" by William Shakespeare (Baptized April 26, 1564 - April 23, 1616).
Specifically, the play ends with Act 5 Scene 8. The significance is the revenge of Malcolm and of Macduff against Macbeth (d. August 15, 1057). Macduff wins a sWord fight against Macbeth. He thereby avenges the earlier massacre of his entire household under Macbeth's orders. He shows Macbeth's head to Malcolm (d. November 13, 1093), who claims the throne of Scotland as his after his imminent coronation at Scone. Malcolm thereby avengesthe death of his father, King Duncan (d. August 14, 1040), at Macbeth's hands.
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