How can changing even one amino acid affect the protein?

changing even one amino acid would change the whole whole sequence hence, change the structure(shape) of the protien because the amino acid ie; the (primary structure) determines the 3 dimensional shape of the protien in the first place,this because the polypeptide posses the positive charge and the negative either side of the peptide bonds these charges form the bonds in the primary-teritary making it into a 3d shape, in conclusion changing one amino acid would disrupt the charges and the way the polypetides are bonded intially changing the protiens structure.

Mefenzo