The fastest way would be to take the Uptown R train (of the N-R-Q, the yellow line) from Whitehall Street-South Ferry to Canal Street. Transfer at Canal Street to the Downtown N train, and take the Downtown N to New Utrecht Avenue-62nd Street.
But the R does not run from 11 PM to 5:30 AM, so if you are traveling during those times, you will have to take a different route. Instead, take the Uptown 1 train (of the 1-2-3, the red line) to 42nd Street-Times Square. Transfer at Times Square to the Downtown N train to New Utrecht Avenue-62nd Street.
You will get off the subway on New Utrecht Avenue. Walk two blocks north on New Utrecht Avenue until you get to 60th Street. Turn left and walk west on 60th Street. Your destination is on the next block, between 13th and 12th Avenues.
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