Is it safe to take excedrin and Zyrtec?

Yes, it is generally considered safe to take Excedrin (which contains acetaminophen, aspirin, and caffeine) and Zyrtec (an antihistamine) together, as there are no known significant drug interactions between them. However, it's important to follow the recommended dosages for both medications. If you have any underlying health conditions or are taking other medications, it's best to consult with a healthcare professional before combining them.