Who lost the most power during the renaissance?

During the Renaissance, the Catholic Church lost significant power due to the rise of Humanism, the Protestant Reformation, and the increasing influence of secular authorities. The Reformation, initiated by figures like Martin Luther, challenged the Church's spiritual and political dominance, leading to the fragmentation of Christianity in Europe. Additionally, the emergence of strong nation-states reduced the Church's political influence as monarchs asserted greater control over their realms. This shift marked a profound transformation in the balance of power in Europe.