Your weight is 220 how many pounds per week should you lose to be close to 160?

No more than 2 to 3 lbs. per week. Keep in mind, you'll probably lose weight faster at first, then you'll do 2-3 lbs. per week, and at the end you'll lose 0 to 1 lb. per week. Over the entire process, you'll average 2 to 3 lbs. per week over approx. 6 months.