The walls of the left ventricle are substantially thicker because it serves as the primary systemic pump of the heart. This chamber is responsible for pumping oxygenated blood to the entire body, requiring greater force and pressure. The increased muscle mass allows the left ventricle to generate the necessary strength to overcome the systemic vascular resistance. In contrast, the right ventricle, which pumps blood to the lungs, has thinner walls due to lower pressure requirements.
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