What strategies can be employed to defend against attack cards and prevent an explosion of kittens in the game of Exploding Kittens?

To defend against attack cards and prevent an explosion of kittens in the game of Exploding Kittens, players can use strategies such as playing skip cards, using defuse cards to prevent exploding kittens, and strategically using cards like favor or shuffle to manipulate the deck. Additionally, keeping track of the cards played and remaining in the deck can help anticipate and counter potential attacks.