Why do people hiccup using methadone?

Hiccups can occur as a side effect of methadone, which is a medication used primarily for pain management and to treat opioid addiction. Methadone acts on the central nervous system, and its effects on neurotransmitters can disrupt normal diaphragm function, leading to involuntary contractions that cause hiccups. Additionally, factors like dosage, individual sensitivity, and interactions with other substances may contribute to the likelihood of experiencing hiccups while on methadone.