Of course you can be best friends with the opposite sex but it also determines who you feel comfortable with and discussing your problems with, so in my opinion it is no problem. I agree with the above poster. I have many male friends and often have them over for dinner. My husband also has a few good female friends who also attend dinners with us. If you are mature, choose your friends carefully then there is no reason a person of the opposite sex can't be your friend without a sexual relationship being involved.
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