To assess whether a bone marrow transplant was successful, I would advise using a chromosome probe specific for the recipient's and donor's chromosomes, such as the centromeric probes of chromosomes 7 and 8. This can help identify chimerism by detecting the presence of both donor and recipient cell populations. Additionally, fluorescence in situ hybridization (FISH) can be employed to analyze specific genetic abnormalities that might indicate transplant success or complications. Monitoring for the presence of donor-specific markers is crucial in evaluating engraftment and potential relapse of the original disease.
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