What disorder would most directly interfere with the emulsification of fats?

Pancreatic insufficiency would most directly interfere with the emulsification of fats. This condition occurs when the pancreas does not produce enough digestive enzymes, particularly lipase, which is essential for breaking down fats into smaller molecules that can be emulsified. Without adequate enzyme production, the digestion and absorption of dietary fats are significantly impaired, leading to malabsorption and fatty stools.