In MLB, that was Jim Gentile of the Baltimore Orioles on May 9, 1961 against the Minnesota Twins at Metropolitan Stadium in Bloomington.
He hit a grand slam in the 1st inning off of Pedro Ramos and a grand slam in the 2nd inning off of Paul Giel. He also had a sacrifice fly in the 8th inning and ended the game, won by the Orioles 13-5, with 9 RBIs.
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