Hydrated antacids may be less effective. The anhydrous sodium carbonate in Eno antacid powder would absorb ambient humidity as soon as it was opened.
However, barring inappropriate storage (excessive heat, broken packaging, wetness around the package) this stuff should last forever in individual serving packages. So, the expiration date is probably either to: encourage you to discard a still-useful product; or federal guidelines set some sort of standard maximum expiration period.
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