Where do you send the 1099 misc copy 1 for SC state tax department?

For South Carolina state tax purposes, you should send Copy 1 of the 1099-MISC form to the South Carolina Department of Revenue. The mailing address is typically listed on the form instructions, but as of my last update, it is: South Carolina Department of Revenue, P.O. Box 125, Columbia, SC 29214-0907. Always verify the address on the latest state tax guidelines to ensure it hasn't changed.