What is the first sign of syphilis?

The first sign of syphilis is typically a painless sore called a chancre, which appears at the site where the bacteria entered the body. This sore usually develops about three weeks after exposure and can be found on the genitals, anus, or mouth. The chancre heals on its own within a few weeks, but if left untreated, syphilis can progress to more serious stages. It's important to seek medical attention if you suspect syphilis or notice any unusual sores.