The sympathetic nervous system (SNS) is primarily located in the thoracolumbar region of the spinal cord and uses norepinephrine as its main neurotransmitter, initiating the "fight or flight" response. In contrast, the parasympathetic nervous system (PNS) originates from the craniOSacral region and primarily utilizes acetylcholine as its neurotransmitter, promoting "rest and digest" activities. Receptors in the SNS include adrenergic receptors, while the PNS mainly has cholinergic receptors. Overall, the SNS prepares the body for stressful situations, while the PNS facilitates recovery and maintenance functions.
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