Could an exhaust issue on a 4-cylinder engine cause it to misfire?

A misfire caused by the ignition system exhausts unburned fuel into the exhaust system that enters the catalytic converter and causes its temperature to rise dramatically. An exhaust issue could cause for cylinder 4 to misfire. The camshaft lobes, which are responsible for opening and closing the intake and exhaust vales, are another source for a misfire and rough running engine. The cam lobes for the No. 4 cylinder should be inspected to see if they have been worn down due to lack of oil or other mechanical problem. A damaged camshaft lobe will not allow a valve to open properly if at all.