How do I know if my meatloaf is done without a meat thermometer?

To check if your meatloaf is done without a meat thermometer, you can cut into the center to ensure it is no longer pink and the juices run clear. The texture should be firm but not dry. Additionally, you can press the top lightly; if it springs back, it's likely cooked through. Always ensure it reaches a safe internal temperature of 160°F for ground beef.