In the end of Shadow Souls Damon takes a bouquet of flowers that are magical and turns him into a human again. It's from a magical creature called a Kitsune, it's the only creature that can turn a vampire into a human again. It was men't for Stephan ( Damon's other vampire brother) as a for Stephan to Elena (Elena is Stephan's girlfriend for now) so they would be together as humans.
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