How many miles is it from Houston Texas to Birmingham Alabama?

640 miles

This is the route:

1. Take OK-51 EAST (Broken Bow Expy) to the MUSKOGEE TURNPIKE - EAST; then continue on the MUSKOGEE TURNPIKE to I-40 EAST to FORT SMITH at EXIT 56B.
2. Take I-40 EAST to I-240 SOUTH to JACKSON, MISS. at EXIT 1E in Memphis, Tennessee.
3. Take I-240 SOUTH & EAST to U.S. 78 EAST to BIRMINGHAM at EXIT 21.
4. Take U.S. 78 EAST (FUTURE I-22) to Birmingham.