What is the most common genetic cause of ASDs spectrum disorders?

The most common genetic cause of autism spectrum disorders (ASDs) is mutations in the CHD8 gene, which have been associated with a significant increase in autism risk. Other notable genetic contributors include changes in the genes linked to synaptic function and neurodevelopment, such as those in the 16p11.2 chromosomal region. Additionally, copy number variations (CNVs) and single nucleotide variants (SNVs) play important roles in the genetic landscape of ASDs. Overall, the genetic basis of ASDs is complex and involves multiple genes and environmental interactions.