How is leprosy colonized?

Leprosy, caused by the bacterium Mycobacterium leprae, is primarily transmitted through respiratory droplets when an infected person coughs or sneezes. Close and prolonged contact with an infected individual is often necessary for transmission, as the bacteria are not highly contagious. It can also be spread through contact with skin lesions or contaminated materials, although this is less common. The exact mechanisms of colonization and infection remain under investigation, as M. leprae has a long incubation period and specific environmental adaptations.