When should quetiapine be taken in order to wake up without being tired?

If you are first starting out on quetiapine, you will probably need a lot for sleep for the first few doses. Also, it will probably hit you pretty quickly. For the first dose, I would suggest you get ready for bed and maybe even be in bed when you take it, and give yourself 10 hours of sleep. After that first time (which is the most extreme), you won't need as much sleep. I have only been taking it for about 3 weeks, so I am still getting used to it. I feel best when i get 8 or 9 house of sleep. Hope that helps!