What effect did the publication of Uncle Tom's Cabin have on the US?

It was the best-seller that dramatised the slavery issue, especially the recent introduction of official slave-catchers, and the Abolitonist reponse to this: the system of safe-houses by which runaways were smuggled into Canada, and known as the Underground Railroad.

apex..............the murder of Harriet Beecher Stowe by a radical proslavery group.