Is under light microscopy-aggregations of Guarnieri bodies are found relevant for diagnosis of smallpox?

Yes, under light microscopy, aggregations of Guarnieri bodies are significant for the diagnosis of smallpox. These inclusions are viral cytoplasmic structures found in infected cells, specifically associated with the variola virus, which causes smallpox. Their presence is a key histopathological feature that aids in identifying smallpox infections in tissue samples. Therefore, detecting Guarnieri bodies is an important diagnostic criterion in clinical pathology.