Where are toxic substances like stimulants depressants and hallucinogens metabolized in the body?

Toxic substances such as stimulants, depressants, and hallucinogens are primarily metabolized in the liver. The liver contains enzymes that break down these compounds, facilitating their elimination from the body. While some metabolism can occur in other organs, such as the kidneys and lungs, the liver is the main site for detoxification processes. After metabolism, the byproducts are often excreted through urine or bile.