Many, many ways. First of all, no drug is safe, even if it is a prescription drug - all drugs have mentally and physically debilitating effects such as cancer, heart attack, mental illness, and a weaker immune system. They also cause addiction, which is the dependence of a person on a certain thing. So you will always be thinking about the next time you will get or use the drug, instead of thinking about what you SHOULD be thinking about, like school or friends or fun. In addition, the things you do while under the influence of drugs have strong consequences. Drugs reduce your reaction time and judgment, so you may say something you regret or get in the car and kill someone, and you won't be fully aware of yourself doing it. Basically, there is no upside!
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