It does depend on the amount of vomit, size of the pool, and your filtration system. A good rule of thumb is no less than 45 minutes after a contaminate is fully cleaned and the area is super chlorinated. If it is baby spit up I normally tell my guards just to scoop it out real fast but if it is larger and spreads I have no problem clearing the pool in the sake of safety. Remember there has never been a documented case of a bloodbourne illness (hep B, HIV, etc.) being spread through the water.
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