Is it safe to take st johns wort with clonezapam?

The St Johns Wort will not cause a problem, but clonezapam has enough side effects of its own for you to deal with. All seizure-based medications are extremely dangerous in the long term, and can provide side-effects which last for a life time. You should see a Naturopathic doctor for an alternative route for dealing with epilepsy, or seizures. In the meantime, make sure that you stay away from artificial sweeteners, and take food-based Vitamin B supplements.

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=== === In this case, yes there is an interaction between those 2 drugs. Otherwise, if you use clonazepam for anxiety or to help sleeping, you won't see a real difference.