What is the cells transmembrane resting potential created by?

The transmembrane resting potential of a cell is primarily created by the differential distribution of ions across the cell membrane, particularly sodium (Na+), potassium (K+), and chloride (Cl-) ions. The Na+/K+ ATPase pump actively transports Na+ out of the cell and K+ into the cell, resulting in a higher concentration of K+ inside and Na+ outside. This unequal distribution, along with the selective permeability of the membrane to K+, leads to a negative charge inside the cell relative to the outside, typically around -70 mV. The resting potential is maintained by the balance between the concentration gradients and the permeability of the membrane to different ions.