To replace the rear pinion bearing on a Ford E-350, first, elevate the vehicle and secure it on jack stands. Remove the driveshaft by unbolting it from the rear axle and mark its position for reinstallation. Next, remove the differential cover, drain the oil, and then use a socket to remove the pinion nut, which will allow you to pull the pinion gear and remove the old bearing. Install the new bearing, reassemble the pinion gear and nut to the specified torque, and reattach the driveshaft and differential cover before refilling with differential oil.
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