Do you have to have a license to drive 49cc scooter?

Depends on which state you live in. Some require a valid drivers license while others offer a "moped only" license. However, in most states, you do not need a motorcycle endorsement to ride scooters that are under 50cc (note for those no in the know: most 50cc scooters are actually under 50cc).

You'll need to check with your states DMV or Dept of Revenue.