The Byzantines developed a deep distrust of Western Christians after the Crusades primarily due to the Fourth Crusade in 1204, during which Crusaders diverted from their mission to the Holy Land and instead sacked Constantinople. This brutal attack led to the establishment of the Latin Empire and significant loss of Byzantine territory and cultural heritage. Additionally, the political and religious differences, including the schism between the Eastern Orthodox and Roman Catholic Churches, further exacerbated tensions, leading Byzantines to view Western Christians with suspicion and resentment.
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