A female's lifetime supply of primary oocytes is established before birth and typically ranges from about 1 to 2 million at birth. However, this number declines significantly during childhood and puberty, with only around 400,000 to 500,000 primary oocytes remaining at the onset of menstruation. Ultimately, only about 400 to 500 of these oocytes will mature and be ovulated throughout a woman's reproductive years. The rest undergo a natural process of atresia, where they degenerate and are reabsorbed by the body.
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