What must be present on tissue or an organ in order for it to respond to the presence of a hormone?

There are certain receptors for some specific hormones on the cell membranes of the target cells of the hormone. They are activated by the hormone and combine with it to form a complex that undergoes a series of receptor mediated reactiions to perform the particular function inside the cell. Some hormones pass through the cell membrane and interact with the receptors present on the membrane of cell organelles. Some hormones like thyroxine interact directly with the nucleus and trigger metabolic enzyme synthesis for increasing BMR