The Word "You" followed by any playfully uttered obscenity of your choosing, or alternatively, if you are aiming to describe a soon-to-be-former friend, one of equal or greater value in a thoroughly less playful tone.
Sprinkle with salty adverbs and garnish with indignation.
Examples:
(in order of increasing severity)
You magnificent %@$!#^&!
You miserable %$#*ing &@%%*#!
You spousally-consanguineous swamp cretin!
You #$@-guzzling gutter-&^#$!
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