What are the side effects for humans taking Methotrexate Prednisone and Celebrex over a period of 12 months?

Long-term use of Methotrexate, Prednisone, and Celebrex can lead to various side effects in humans. Methotrexate may cause liver toxicity, bone marrow suppression, and gastrointestinal issues, while Prednisone can result in weight gain, increased blood sugar, and osteoporosis. Celebrex may increase the risk of cardiovascular events and gastrointestinal bleeding. Regular monitoring by a healthcare provider is essential to manage and mitigate these potential side effects.