I am 42 my period has always been regular for last year has been every 21-25 days now missed last 2 months took 2 pregnancy tests both neg extremely tired in mornings could it be menopause?

At 42, it's possible that you are experiencing perimenopause, which can cause changes in your menstrual cycle and symptoms like fatigue. Irregular periods and missed cycles are common as hormone levels begin to fluctuate. However, fatigue can also be caused by various factors, so it's important to consult a healthcare provider to discuss your symptoms and rule out other potential causes.