Formulae to separate ergotamine from caffeine?

To separate ergotamine from caffeine, one effective method is liquid-liquid extraction, utilizing a solvent that selectively dissolves one compound over the other based on their solubility properties. Ergotamine, being more polar, can be extracted using a polar solvent, while caffeine, which is less polar, remains in the aqueous phase. Additionally, chromatography techniques, such as high-performance liquid chromatography (HPLC), can be employed to achieve further separation based on differences in their chemical interactions with the stationary phase.