What was the one New World disease that was transferred to Afro-Eurasia as a result of the Columbian Exchange How did it spread?

The one notable New World disease that was transferred to Afro-Eurasia during the Columbian Exchange was syphilis. It is believed to have spread through sailors returning from the Americas to Europe in the late 15th century, leading to outbreaks in various parts of Europe. The disease was characterized by its rapid transmission through sexual contact and became widespread, causing significant public health concerns in the years that followed.