When do puppies come off the nipple?

Puppies typically begin to wean off their mother's milk around 3 to 4 weeks of age. During this time, they gradually start to eat solid food, usually a specially formulated puppy food, while still nursing occasionally. By about 6 to 8 weeks, most puppies are fully weaned and rely entirely on solid food. It's important for them to transition smoothly to ensure proper nutrition and development.