How much oxycodone is safe to take?

The safe dosage of oxycodone is strongly dependent upon tolerance and to a lesser extent individual biochemistry. A common starting dose of oxycodone for pain management is 5mg every six hours. Individuals who have taken opioids for long periods of time can take hundreds of milligrams per day and still be completely functional, although these doses could easily kill an opioid naive person. The general rule of opioid dosing is start low and gradually titrate the dose upwards. Finally, it is very important that this medication is not mixed with other opioids or depressants, as these combinations can vastly lower the safe dose and increase the risk of overdose.