Is it possible to put a V8 in a 95 4x4 S-10 blazer?

they do it all the time, I'm doing it with an 83, same frame really and very similar body under the outer skin. depending on what engine an what accessories you have you might have to chop up your air box for your hvac(heating and air conditioning box). just search s10 v8 and tons of pages will pop up