Depends. If you have used control panel - uninstall to get rid of a program, but part of it still remains in Program Files, then by all means attempt to delete it there.
On the other hand if you want to keep one a program, do not delete it.
It depends on what the file is. If it is a system file, you do not want to delete it as it would more than likely destroy some of the functions of your computer.
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