Which substances can impair fitness to drive in a similar way to alcohol?

Substances that can impair fitness to drive similarly to alcohol include various drugs, such as opioids, benzodiazepines, and other sedatives, which can affect coordination, reaction times, and judgment. Additionally, recreational drugs like marijuana and stimulants can also impair cognitive functions and motor skills. Certain over-the-counter medications, especially those with antihistamines, can cause drowsiness and reduced alertness. Overall, any substance that alters mental or physical capabilities poses a risk while driving.