Your uncle and you have a home titled together and he has now died but I have made the payments for the last four years does his wife have a claim on your house?

Did your deceased uncle leave a will? He may have left some instruction as to who inherits his stake in the house. If he didn't, then yes, his wife will inherit his stake in the house, despite the fact that you have made the payments for the past four years (although you can ask her to make her share of the payments).